Mini-ITX still the best small form factor board?

Generally speaking, noise has little to do with form factor. It has more to do with the fans (speed, model, location, etc.) in the chassis than anything.

Mini-ITX is extremely limiting and expensive relative to the features.

I’d go for a plain ATX NK4 if I were you. It’s the easiest to build, cheapest, and allows for the most options for future expansion.

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